ALZET® Products - Pump Selection

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A pilot study to determine penile oxygen saturation before and after vacuum therapy in patients with erectile dysfunction after radical prostatectomy. Basic material used in manufacturing several of the glycols, in making acrylonitrile, ethanolamines; used in making detergents; petroleum emulsifiers; also used as a rocket propellant. As they ferment they become increasingly acidic, making them more difficult to handle corrosion-wise as they age. The smaller the grade number, the less viscous the grease. Rosin is combustible; gives off flammable vapors when heated. Varies from 40cps to 40, cPs.

Rotary Lobe Pump

Animal testing

Exercise of the chest, back and arms, legs, paired with an elevated heart rate are synonymous with increased circulation and good blood flow. But is this true for all organs in the body? Interestingly it is not. There is one male organ that is different, the penis.

The penis does not receive enhanced blood flow from traditional forms of physical activity and exercise. A very minimal amount of blood flow exists in a flaccid or non-erect penis , which is the natural state of the penis. The presence of a minimal amount of oxygen in penile tissues is normal when the penis is not erect. The medical term for this is hypoxia.

Hypoxia is defined as a deficiency in the amount of oxygen reaching the tissues. How does our penis stay healthy in a state which is normally and naturally flaccid and with little oxygen? The tissues in the penis require oxygenation just like other organs and tissues in the body. If not through traditional means of physical activity or exercise, then how?

The answer to this question is straight forward, erections. Penis health requires reoccurring erections to increase blood flow that brings oxygen to otherwise flaccid penile tissues. We naturally think of erections and sexual intercourse going together. Does this mean the only way to exercise or bring oxygen to tissues in the penis is sexual intercourse? Furthermore, if daily exercise is necessary, would that mean daily sexual intercourse is the key to penile health?

Truly this would not be realistic. So, nature has provided a solution. The most effective natural male enhancement is not an herb or supplement, it is spontaneous erections that occur every night while healthy adult men sleep.

The phase of sleep in which this happens is known as R. M sleep, during at which time erections occur nightly. The male body has developed a natural way to exercise itself by delivering oxygen to penile tissues that are normally non-erect or flaccid.

Furthermore, natural penis exercises occur at regular intervals or frequencies in a hour time-period. Nocturnal erections occur in a prescriptive way, dictated by a biological or circadian rhythm. Erections during sleep are the form of exercise that carries nutrient-rich oxygen blood flow to flaccid penile tissues. So, penis exercises are very real, naturally occurring and maintain penile health.

They are often described as nocturnal tumescence, nocturnal erections, or referred to in popular culture as morning glory. However, there are situations in life that disrupt this normal method. Certain disease such as diabetes , prostate cancer , or hypertension medications for heart disease, can interfere with and eliminate the process of naturally occurring nocturnal erections as a side effect of an underlying medical condition.

What happens to the penis without natural male enhancement in the form of exercise provided through nocturnal erections? Furthermore, oxygen is critical not only to the health of tissues but also to the presence of tissues.

The absence of natural penis exercise and lack of recurring nocturnal erections every 24 hours during sleep is thought to be a fundamental cause of erectile dysfunction. The lack of free oxygen, transported to the penis by hemoglobin is theoretically detrimental to the synthesis of Nitric Oxide. Corporal hypoxia predisposes the penis to cavernous fibrosis.

This cell death brings about atrophy of penile tissues leading to penile fibrosis or hardening of vessels and shrinkage of the penis. If a disease or physical condition has eliminated naturally occurring nocturnal erections, how does the penis get the exercise it needs to overcome hypoxia and oxygenate flaccid penile tissues that require daily exercise? The simple answer to the lack of oxygenation of tissues that are absent when nocturnal erections go away is more erections.

Use it or lose it , sounds like a cliché but it truly applies to penile health. The best way to have great erections is to have multiple erections, this constantly oxygenates penile tissues to keep the penis healthy. The reason why the penis pump is the best way to exercise the penis is that creating and releasing several erections in one exercise session with a penis pump mimics how the body creates and releases erections in R.

No other medical intervention can create and release multiple erections in one sitting. No oral medication, injection, or penile implant has the ability to create and release multiple erections in one therapeutic session.

A penis pump is great for creating and releasing multiple erections if used properly. Multiple clinical studies conducted on prostate cancer survivors substantiate this claim, below are just a couple of the statements made, and the publications that released the peer-reviewed clinical studies: A pilot study to determine penile oxygen saturation before and after vacuum therapy in patients with erectile dysfunction after radical prostatectomy.

The use of a VED has significant benefits for patients both with regard to cost and invasiveness when compared with other penile rehabilitation protocols. This helps inhibit apoptosis and prevent cavernous tissue fibrosis. For example, a 2 month infusion would be achieved by implanting a 4 week pump, removing it after one month, and replacing it with a fresh 4 week pump. You could also implant a 6 week pump model, followed by a 2 week pump model. This reference list includes published studies in which infusions of up to 18 months duration have been accomplished, and up to 36 serial implantations have been performed on a single animal.

Click here for a list of references on extended duration studies. Because of its mechanism of operation, the ALZET pump is well suited for administering a wide range of compounds regardless of their molecular weight.

The molecular weight has no impact on the delivery or function of the pump. How does the pump work? Successful delivery of an enormous range of compounds has been reported in the literature Click here for a list of all agents that have been delivered using ALZET pumps.

For poorly soluble compounds, a larger pump with a faster flow rate allowing for a lower drug concentration , may be required to administer the required dose. List of pump models and reservoir volumes Tips on selecting a vehicle. When working with compounds that are expensive, or in limited supply, the driving factor in choice of pump may be small reservoir capacity.

Volumes smaller than the reservoir capacity of a single pump can be administered successfully via catheter. Depending on the solubility of the compound, administering a larger dose quickly will require a pump with a relatively higher flow rate.

Some studies have a daily dose as the goal. Use the following equation or our interactive calculator to determine the daily dose delivered by a particular pump:.

Depending upon the size of the animal e. Rates and durations listed for ALZET pumps are based on use in vivo in mammals unless otherwise specified. In alternate settings, such as in vitro or in other species, the pumping rate and duration may differ since they are affected by temperature and osmolality.

Both temperature and osmolality affect the rate at which water crosses the semi-permeable membrane and enters the osmotic sleeve. The graph on the left shows the representative pumping rates for two pump models from 4 degrees to over 40 degrees in 0. Use the following equations, or the interactive calculator , to predict the pumping rate in heterothermic animals or in those whose body fluids are hypertonic relative to mammals.

Choose a pump model: Request a custom bibliography search or select from our list of citations available on-line: Pump Selection ALZET pumps are available in a variety of sizes, durations and flow rates to meet a wide range of research needs. When choosing a pump model , consider the following: Animal Considerations ALZET pumps can be implanted subcutaneously or intraperitoneally following the animal size guidelines below.